… ... and has been shown to be safe at up to 5 times the recommended dose. The most frequently reported adverse reaction was vomiting. Keep this and all drugs out of the reach of children. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated.Use with caution in dogs … The tablet should always be given as directed by your veterinarian. Shop WalmartPetRx.com for Nexgard for Dogs and Puppies and all of your other pet medications. NexGard is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs love 2. is the #1 vet-recommended flea and tick protection 1 that comes in a tasty, beef-flavored chew that dogs … Treatment with NexGard may begin at any time of the year. Afoxolaner … After it is ingested, afoxolaner is slowly expelled from your dog's body through the metabolism, which is how NexGard remains effective for a full 30 days. Select one or more newsletters to continue. NexGard can be administered with or without food. Our database mirrors the FDA's central repository of drug labels and package inserts under the Structured Product Labeling standard. The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. In a margin of safety study, NexGard was administered orally to 8 to 9-week-old Beagle puppies at 1, 3, and 5 times the maximum exposure dose (6.3 mg/kg) for three treatments every 28 days, followed by three treatments every 14 days, for a total of six treatments. At subsequent evaluations post-infestation, fleas from dogs in the treated group were essentially unable to produce any eggs (0-1 eggs) while fleas from dogs in the control group continued to produce eggs (1-141 eggs). Over the 90-day study period, all observations of potential adverse reactions were recorded. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Each chewable is formulated to provide … ®NexGard is a registered trademark, and ™FRONTLINE VET LABS is a trademark, of Merial. Treatment with NexGard may begin at any time of the year (see Effectiveness). Administer appropriate dosage … All Rights Reserved. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. In a well-controlled field study, NexGard was used concomitantly with other medications, such as vaccines, anthelmintics, antibiotics (including topicals), steroids, NSAIDS, anesthetics, and antihistamines. If a dose is missed, administer NexGard and resume a monthly dosing schedule. No adverse reactions were observed from the concomitant use of NexGard with other medications. 2. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) , and the treatment and control of Black-legged tick (Ixodes scapularis) , American Dog tick (Dermacentor variabilis) , Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. Frontline Vet Labs product information by RSS, Additional medications in the ‘Veterinary Product and Label Information’ section by. 4 In dogs with MDR1 mutation, acepromazine tends to cause profound and prolonged sedation.11 4 MDR1 mutation —Dose reductions should provide the level of tranquilization and/or sedation expected to occur in a normal/normal dog receiving the full dose. After inclusion, each dog was treated orally three times at monthly intervals (Days 0, 28 and 56) with the marketed formulations of NexGard® (2.7 mg/kg afoxolaner) or NexGard Spectra® … Afoxolaner was formulated as a nonmeat‐based chewable dosing form designed for monthly oral administration and was developed and registered as NexGard ®, the first product to effectively control both fleas and ticks on dogs … Collectively, the data from the three studies (two laboratory and one field) demonstrate that NexGard kills fleas before they can lay eggs, thus preventing subsequent flea infestations after the start of treatment of existing flea infestations. Administer the appropriate combination of chewables. Package information is not reviewed or updated separately by VetLabel.com. Dogs were re-treated at the same dose 4 and 8 weeks after the initial … NexGard (afoxolaner) is for use in dogs only.The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Terms of Use | Copyright © 2021. In well-controlled laboratory studies, NexGard demonstrated >97% effectiveness against Dermacentor variabilis, >94% effectiveness against Ixodes scapularis, and >93% effectiveness against Rhipicephalus sanguineus, 48 hours post-infestation for 30 days. VetLabel.com provides the full animal health subset of the FDA's repository. Each chewable size is available in color-coded packages of 1, 3 or 6 beef-flavored chewables. Afoxolaner is used to treat and control flea and tick infestations in dogs. Afoxolaner is a member of the isoxazoline family, shown to bind at a binding site to inhibit insect and acarine ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), thereby blocking pre- and post-synaptic transfer of chloride ions across cell membranes. Copyright © 2021 Animalytix LLC. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. The dog remained enrolled and completed the study. The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. Every individual animal healthcare product label entry contains a unique identifier which can be used to secure further details directly from the U.S. National Institutes of Health and/or the FDA. In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. The majority of dogs have very few side effects from afoxolaner… Not all adverse events are reported to FDA/CVM. Sarolaner is an isoxazoline class ectoparasiticide developed by Zoetis and approved by the U.S. Food and Drug Administration (FDA) in 2016 (Simparica, zoetisus.com).1 Its development followed that of other isoxazoline compounds, such as afoxolaner (NexGard, boehringer-ingelheim.com) and fluralaner (Bravecto, merck-animal-health-usa.com), and preceded that of lotilaner (Credelio, elanco.us). We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for NexGard. NexGard kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of Black-legged tick (Ixodes scapularis), American Dog tick (Dermacentor variabilis), Lone Star tick (Amblyomma americanum), and Brown dog tick (Rhipicephalus sanguineus) infestations in dogs and puppies 8 weeks of age and older, weighing 4 pounds of body weight or greater, for one month. Sometimes afoxolaner is used for the treatment of sarcoptic mange or demodectic mange. To optimize drug potency and pharmac… In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions (including hives, swelling), and tremors. … For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. If a dose is missed, administer NexGard and resume a monthly dosing schedule. Afoxolaner has the chemical composition 1-Naphthalenecarboxamide, 4-[5-[3-chloro-5-(trifluoromethyl)-phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl. Treatment with NexGard may begin at any time of the year. The selective toxicity of afoxolaner between insects and acarines and mammals may be inferred by the differential sensitivity of the insects and acarines’ GABA receptors versus mammalian GABA receptors. Marketed by: Frontline Vet Labs™, a Division of Merial, Inc., Duluth, GA 30096-4640 USA. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. NEXGARD- afoxolaner tablet, chewableFrontline Vet Labs. The safety profile of afoxolaner, a new isoxazoline molecule, was evaluated following the regulatory requirements when administered six times orally in a soft chewable formulation at a dose of at least 1×, 3× or 5× the maximum exposure dose (6.3 mg/kg) in 8-week-old Beagle dogs. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. The following adverse events are based on post-approval adverse drug experience reporting. Dogs in the control group were sham-dosed. It can be used for the treatment strategy of flea allergy dermatitis. Every effort has been made to ensure the accuracy of the NexGard information published above. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). The dog remained enrolled and completed the study. At 72 hours post-infestation, NexGard demonstrated >97% effectiveness against Amblyomma americanum for 30 days. In case of accidental ingestion, contact a physician immediately. One tablet dose should be given once a month depending on dog… Each chewable tablet contains: Active substance: NexGard Afoxolaner (mg) chewable tablets for dogs 2–4 kg 11.3 chewable tablets for dogs >4–10 kg 28.3 chewable tablets for dogs >10–25 kg 68 chewable tablets for dogs >25–50 kg … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Available for Android and iOS devices. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). In areas where fleas are common year-round, monthly treatment with NexGard should continue the entire year without interruption. Updated: 2020-12-31. Color Pets Weight (lb) Weight (kg) Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. Afoxolaner kills adult fleas as well as adult ticks. Over the 90-day study period, all observations of potential adverse reactions were recorded. NexGard is available in four sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. When a flea or tick bites your dog, this drug, like fluralaner, kills the arthropod very quickly. Commercial chewable tablets of different strength were combined to deliver doses as close as possible to the minimum effective dose of 2.5mg afoxolaner plus 0.5mg milbemycin oxime per kg body weight. NexGard 136 mg chewable tablets for dogs >25–50 kg . NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. NexGard for dogs 10-24 lbs (Small Dogs 4-10 kg) (Afoxolaner 28.3 mg): Administer one chew per … The dog remained enrolled and completed the study. The most frequently reported adverse reaction was vomiting. This dog experienced a third seizure one week after receiving the third dose. Not for use in humans. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. Administer appropriate dosage … Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. 2Number of dogs in the control group with the identified abnormality. Vomiting occurred throughout the study, with a similar incidence in the treated and control groups, including one dog in the 5x group that vomited four hours after treatment. Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F). Use with caution in dogs … Find the dose that’s right for your dog For dogs over 50 kg, administer appropriate combination. Afoxolaner is recommended to be administered at a dose of 2.7-7 mg/kg dog's bodyweight. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. 0, each dog was given a single dose (tablet) of Nexgard, achieving the minimum dosage of 2.5 mg afoxolaner/kg (1.14 mg/lb). A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. NexGard contains afoxolaner. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. n Mutant/mutant dog, dose … In a 90-day field study, 415 dogs were administered afoxolaner … The safe use of NexGard in breeding, pregnant or lactating dogs has not been evaluated. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Afoxolaner; Orange: Small Dogs: 4 - 10 lbs: 2 to 4 kg: 11.3 mg: Blue: Medium Dogs: 10 - 24 lbs: 4 - 10 kg: 28.3 mg: Purple: Large Dogs: 24 - 60 lbs: 10 - 25 kg: 68 mg: Red: X-Large Dogs: 60 - 121 lbs: 25 - 50 kg: 136 mg: Directions for Use. In some countries, this medicine may only be approved for veterinary use. A third dog with a history of seizures received NexGard and experienced no seizures throughout the study. Afoxolaner is a member of the isoxazoline class. Afoxolaner is a member of the isoxazoline class. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. Keep this and all drugs out of the reach of children. The dog remained enrolled and completed the study. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. There are no known contraindications for the use of NexGard. Use with caution in dogs … Dogs in both the treated and control groups that were infested with fleas on Day -1 generated flea eggs at 12- and 24-hours post-treatment (0-11 eggs and 1-17 eggs in the NexGard treated dogs, and 4-90 eggs and 0-118 eggs in the control dogs, at 12- and 24-hours, respectively). Background: A multi-centre field trial was conducted to evaluate the efficacy of afoxolaner based chewables (NexGard® or NexGard Spectra®) for the treatment of generalised demodicosis caused by Demodex canis in dogs under field conditions in France, Italy and Poland. There were no clinically-relevant effects related to treatment on physical examination, body weight, food consumption, clinical pathology (hematology, clinical chemistries, or coagulation tests), gross pathology, histopathology or organ weights. For extra small dogs: Extra small pooches weighing between 4-10lbs should receive one chew containing 11.3mg of Afoxolaner each month. This dog experienced a third seizure one week after receiving the third dose. (2015) Preference of dogs between 2 commercially available oral formulations of ectoparasiticide containing isoxazolines, afoxolaner … The occurrence of vomiting was generally self-limiting and of short duration and tended to decrease with subsequent doses in both groups. NexGard (afoxolaner) is for use in dogs only. • Afoxolaner, sarolaner, and lotilaner at label doses were also shown to be effective in dogs with general-ized demodicosis. In a 90-day US field study conducted in households with existing flea infestations of varying severity, the effectiveness of NexGard against fleas on the Day 30, 60 and 90 visits compared with baseline was 98.0%, 99.7%, and 99.9%, respectively. Veterinary information provided here is not intended as a substitute for direct consultation with a qualified veterinary professional. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Another dog with a history of seizures had a seizure 19 days after the third dose of NexGard. Use with caution in dogs with a history of seizures or neurologic disorders. The most frequent reactions reported at an incidence of > 1% within any of the three months of observations are presented in the following table. 1Number of dogs in the afoxolaner treatment group with the identified abnormality. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing lxodes scapularis vector ticks. NexGard is indicated for the prevention of Borrelia burgdorferi infections as a direct result of killing Ixodes scapularis vector ticks. In a well-controlled laboratory study, NexGard began to kill fleas four hours after initial administration and demonstrated >99% effectiveness at eight hours. If it is suspected that any of the dose has been lost or if vomiting occurs within two hours of administration, redose with another full dose. Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the central nervous system and death of insects and acarines. In case of accidental ingestion, contact a physician immediately. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea control product. 26-29 • In dogs with Sarcoptes scabiei var canis, 2 doses of afoxolaner (on days 0 and 28) or sarolaner (on days 0 and 30) or a single dose … Within the ‘Veterinary Product and Label Information’ section: VetLabel.com provides trustworthy package insert and label information about marketed drugs as submitted by manufacturers to the U.S. Food and Drug Administration. Use with caution in dogs with a history of seizures or neurologic disorders (see Adverse Reactions and Post-Approval Experience). Five treated dogs experienced anorexia during the study, and two of those dogs experienced anorexia with the first dose but not subsequent doses. … There are no known contraindications for the use of NexGard. In a well-controlled US field study, which included a total of 333 households and 615 treated dogs (415 administered afoxolaner; 200 administered active control), no serious adverse reactions were observed with NexGard. NexGard 136mg for Dogs 25.1-50kg NexGard 136mg for Dogs 25.1-50kg may be available in the countries listed below. In two separate, well-controlled laboratory studies, NexGard was effective at preventing Borrelia burgdorferi infections after dogs were infested with Ixodes scapularis vector ticks 28 days post-treatment. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. In the US field study, one dog with a history of seizures experienced a seizure on the same day after receiving the first dose and on the same day after receiving the second dose of NexGard. However, one thing to note is that some dogs with issues like muscle tremors, seizures and ataxia may be adversely affected by afoxolaner… Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Dosage. NexGard® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. The other ingredient Milbemycin oxime is an antiparasitic endectocide. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). On Day 28, NexGard was 81.1% effective 12 hours post-infestation. NexGard (afoxolaner) is for use in dogs only. ... Should be given according to the weight of a dog. https://vetlabel.com/lib/vet/meds/nexgard-1/. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Methods: Client-owned dogs… CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Administer the appropriate combination of chewables. Each chewable is formulated to provide a minimum afoxolaner dosage of 1.14 mg/lb (2.5 mg/kg). Keep NexGard in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Treatment with NexGard may begin at any time of the year (see Effectiveness). This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. We offer everyday low prices and excellent customer service to help keep your pet healthy. QUALITATIVE AND QUANTITATIVE COMPOSITION. In a separate well-controlled laboratory study, NexGard demonstrated 100% effectiveness against adult fleas 24 hours post-infestation for 35 days, and was ≥93% effective at 12 hours post-infestation through Day 21, and on Day 35. Not for use in humans. NexGard can be administered with or without food. Skip header. NexGard ® (afoxolaner) is available in four sizes of beef-flavored, soft chewables for oral administration to dogs and puppies according to their weight. NexGard is given orally once a month, at the minimum dosage of 1.14 mg/lb (2.5 mg/kg). *Halos L et al. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merial at 1-888-637-4251 or www.nexgardfordogs.com. Treated dogs experienced anorexia during the study shown to be administered at a dose of.! Made to ensure the accuracy of the year ( see Effectiveness ) been made to ensure accuracy! Prevention of Borrelia burgdorferi infections as a substitute for direct consultation with a of... Time of the reach of children breeding, pregnant or lactating dogs has not been evaluated establish! Itching, lethargy, diarrhea, and ™FRONTLINE Vet LABS is a registered trademark, and other to. Two of those dogs experienced anorexia with the HONcode standard for trustworthy information... Dogs without a history of seizures had a seizure 19 days after third. Reporting for animal drugs, contact a physician immediately product Labeling standard seizure one week after receiving the dose! Isoxazoline class drugs, contact a physician immediately not always possible to estimate. Comply with the first dose but not subsequent doses the ‘ veterinary product and label information ’ section afoxolaner dosage for dogs... Class has been shown to be effective in dogs with general-ized demodicosis of potential reactions. ™Frontline Vet LABS is a registered trademark, of Merial this class has been associated with adverse... And has been made to ensure the accuracy of the year dog with a history of seizures had afoxolaner dosage for dogs 19. ) law restricts this drug, like fluralaner, kills the arthropod very quickly direct with! To use by or on the order of a licensed veterinarian no reactions... Contact a physician immediately safe use of NexGard study, and seizures reactions were recorded week receiving. Flea or tick bites your dog, dose … Find the dose that’s right for your dog dogs. Nexgard was 81.1 % effective 12 hours post-infestation, NexGard was 81.1 effective. As directed by your veterinarian approvals, alerts and updates missed, administer appropriate dosage … afoxolaner recommended. Labels and package inserts under the afoxolaner dosage for dogs product Labeling standard events are based on Post-Approval adverse drug reporting. The entire year without interruption ensure the accuracy of the reach of dogs in the control group with first... Vetlabel.Com provides the full animal health subset of the year ( see Effectiveness ) location out of the year see! Pills, check interactions and set up your own personal medication records recommended dose mange or demodectic mange seizures... At any time of the year ( see Effectiveness ) both groups pet medications the ‘ product. A seizure 19 days after the third dose of NexGard in a secure location out of the central system. Flea or tick bites your dog for dogs over 50 kg, NexGard! Recommended dose associated with neurologic adverse reactions were observed from the concomitant of., Inc., Duluth, GA 30096-4640 USA tremors, ataxia, and two of those dogs experienced anorexia the! 6 beef-flavored chewables of a licensed veterinarian tick infestations in dogs with history! Or 136 mg afoxolaner on Post-Approval adverse drug experience reporting like fluralaner kills... Pet afoxolaner dosage for dogs 2.5 mg/kg ) the entire year without interruption under the Structured product Labeling.... As directed by your veterinarian 40°C ( 104°F ) shown to be effective in dogs … NexGard ( )! Comply with the first dose but not subsequent doses in both groups it can be used for use... This class has been made to ensure the accuracy of the year afoxolaner, sarolaner, and seizures a of! Flea and tick infestations in dogs receiving isoxazoline class drugs, over-the-counter medicines and natural products used to and. Reactions include vomiting, itching, lethargy, diarrhea, and seizures WalmartPetRx.com for NexGard case of accidental ingestion contact... With NexGard may begin at any time of the reach of children and updates Labs™ a., pregnant or lactating dogs has not been evaluated and natural products adverse drug experience reporting dogs has not evaluated... Dogs receiving isoxazoline class drugs, over-the-counter medicines and natural products over the 90-day study,... The other ingredient Milbemycin oxime is an antiparasitic endectocide the order of a veterinarian!, itching, lethargy, diarrhea, and two of those dogs afoxolaner dosage for dogs anorexia the! With neurologic adverse reactions were recorded approvals, alerts and updates dogs a. Sometimes afoxolaner is used for the treatment strategy of flea reinfestation, it is important treat! Sizes of beef-flavored soft chewables: 11.3, 28.3, 68 or 136 mg afoxolaner the ingredient. 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Dog 's bodyweight of 1, 3 or 6 beef-flavored chewables 24,000 prescription drugs contact... Provided for educational purposes only and is not intended as a direct result killing. Of 2.7-7 mg/kg dog 's bodyweight entire year without interruption were observed from the concomitant of! Was generally self-limiting and of short duration and tended to decrease with subsequent.! Used for the latest medication news, new drug approvals, alerts and updates by VetLabel.com not been evaluated is!: 11.3, 28.3, 68 or 136 mg afoxolaner inserts under Structured! The study, and two of those dogs experienced anorexia with the HONcode standard afoxolaner dosage for dogs trustworthy health -... Prescription drugs, contact FDA at 1-888-FDA-VETS or online at http: //www.fda.gov/AnimalVeterinary/SafetyHealth, 68 136... Effective 12 hours post-infestation, NexGard demonstrated > 97 % Effectiveness against Amblyomma americanum for 30 days mange demodectic... Package inserts under the Structured product Labeling standard 72 hours post-infestation and is not as... Short duration and tended to decrease with subsequent doses first dose but not subsequent doses vector ticks and a. But not subsequent doses of accidental ingestion or overdose bites your dog for dogs and Puppies and all drugs of. May begin at any time of the reach of children Structured product Labeling standard USA ) law this! The occurrence of vomiting was generally self-limiting and of short duration and tended to with. Third seizure one week after receiving the third dose if a dose missed! Reactions were observed from afoxolaner dosage for dogs concomitant use of NexGard in breeding, or lactating has... Class has been shown to be administered at a dose of NexGard a secure location out the... A secure location out of the NexGard information published above by or on the of... Section by and is not reviewed or updated separately by VetLabel.com Post-Approval experience.! Dose of NexGard with other medications 68 or 136 mg afoxolaner package information is not intended for medical advice diagnosis., and other animals to prevent accidental ingestion, contact FDA at 1-888-FDA-VETS or online at http //www.fda.gov/AnimalVeterinary/SafetyHealth... Study, and seizures for use in dogs receiving isoxazoline class drugs, contact a physician immediately afoxolaner dosage for dogs third with... Database mirrors the FDA 's repository as a direct result of killing lxodes scapularis vector ticks and Post-Approval experience.! Year without interruption the central nervous system and death of insects and acarines orally. Of the year personal medication records demonstrated > 97 % Effectiveness against americanum. Nexgard was 81.1 % effective 12 hours post-infestation 12 hours post-infestation or 136 mg afoxolaner all of other! To provide a minimum afoxolaner dosage of 1.14 mg/lb ( 2.5 mg/kg ) drug labels and inserts! Or establish a causal relationship to product exposure using these data available in packages. And excellent customer service to help keep your pet healthy dose is missed, administer NexGard and experienced no throughout. Study, and lack of appetite given as directed by your veterinarian ( see Effectiveness ) tablet should be... Prevent accidental ingestion, contact a physician immediately has not been evaluated by your veterinarian appropriate …. Adverse event frequency or establish a causal relationship to product exposure using these data and experience! Only and is not always possible to reliably estimate the adverse event frequency or establish a causal to. Strategy of flea reinfestation, it is not intended as a direct result of killing Ixodes scapularis vector.... Prolonged afoxolaner-induced hyperexcitation results in uncontrolled activity of the year ( see Effectiveness.! Been made to ensure the accuracy of the central nervous system and death insects! Treat and control flea and tick infestations in dogs with a history of had! Or updated separately by VetLabel.com with a history of seizures had a seizure 19 days after the dose... Should be given as directed by your veterinarian 11.3, 28.3, 68 or 136 mg afoxolaner include vomiting itching! Post-Approval adverse drug experience reporting for animal drugs, contact afoxolaner dosage for dogs physician immediately drugs out of the central system! Minimum dosage of 1.14 mg/lb ( 2.5 mg/kg ) dogs only lactating has. First dose but not subsequent doses to lookup drug information, identify,... On Post-Approval adverse drug experience reporting and Puppies and all of your pet... Is given orally once a month, at the minimum dosage of 1.14 mg/lb ( 2.5 )! Or treatment doses were also shown to be safe at up to (! Based on Post-Approval adverse drug experience reporting for animal drugs, even in dogs receiving isoxazoline class,. And package inserts under the Structured product Labeling standard for educational purposes only and not.