To date, only one study that includes two field trials has examined the effects of clothianidin seed-treated canola on honey bees, Apis mellifera L., and found no adverse effect on colony health at residue levels ranging from 0.9 to 3.7 ppb (Scott-Dupree, personal communication). Clothianidin, C(E)-N-((2-chloro-5- thiazolyl) Symptoms of toxicity are rarely seen, unless your dog licks the imidacloprid directly. We also observed behavioral effects of clothianidin. Intravenous injections of protamine (protamines) may cause a sudden fall in blood pressure, bradycardia, pulmonary hypertension, dyspnea, or transitory flushing and a feeling of warmth.There have been reports of anaphylaxis that resulted in respiratory embarrassment (see PRECAUTIONS).Other reported adverse reactions include systemic hypertension, nausea, vomiting and … Migraines are no longer thought to be caused by blood menopausal transition and after menopause women can experience a wide range of symptoms. Effect of the Neonicotinoid Insecticide Clothianidin on NF-κB Signaling and Immune Response. The toxicity of clothianidin varies, depending on the length of exposure. Eye Itching 7. Irrespective of whether clothianidin is responsible for the bee deaths, the BvL (=German Consumer Protection / Food Administration) will investigate dust clouds caused by pneumatic sowing machines; any side effects of clothianidin and other seed treatments, and will modify usage permits if needed. 2008, Gu. While generally safe and effective when prescribed by a veterinarian, chlorhexidine can cause side effects in some animals. et al. (Beyond Pesticides, May 2, 2019) Researchers have documented an increase in food and drinking water residues of neonicotinoids, insecticides linked to breast cancer. Prior to the implementation of the ban in 2013, which did not really affect neonicotinoid seed treatment use until the autumn of 2014, three main products were used (Fig. Neonicotinoids are a new class of insecticides chemically related to nicotine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Clothianidin effects on colony strength were only observed if unrealistically high residue levels in the pollen were simulated. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. We conducted laboratory experiments to investigate the lethal and sublethal effects of clothianidin on bumble bee, Bombus impatiens Cresson, colony health and foraging ability. 2015). This site complies with the HONcode standard for trustworthy health information: verify here. Imidacloprid is a systemic insecticide that acts as an insect neurotoxin and belongs to a class of chemicals called the neonicotinoids which act on the central nervous system of insects. blood in the urine or stools. Occupationally, clothianidin handling requires protective gear such as chemical gloves, boots, long-sleeved chemical suit, goggles, and a respiratory mask (full-face). Clothianidin is a neonicotinoid insecticide sold by Bayer CropScience under the brand names Poncho, Prosper, and Votivo. Bumble bee colonies were exposed to 6 ppb clothianidin, representing the highest residue levels found in field studies on pollen, and a higher dose of 36 ppb clothianidin in pollen. Drug information provided by: IBM Micromedex. The Meeting concluded that clothianidin is not a developmental neurotoxicant. While clothianidin may cause slight eye irritation, it is not expected to be a skin sensitizer or irritant. Along with its needed effects, a medicine may cause some unwanted effects. Clothianidin is used in the following food crops: almonds, wine grapes, walnuts, broccoli, cauliflower, tomatoes, cabbage, lettuce, cantaloupe, spinach, bell peppers, potatoes, melons, pomegranates, sweet potatoes, watermelons, cucumbers, pecans, celery, kale, Brussels sprouts, collards, mustard, pears, artichokes, squash, and peaches. EFED expects adverse effects to bees if clothianidin is allowed to be sprayed on blooming, pollen- shedding, or nectar producing parts of plants. See below for a comprehensive list of adverse effects. Pohorecka, K., et al., 2013. Metalaxyl is harmful if swallowed, and it can cause an allergic skin reaction. Not likely to be carcinogenic to humans. et al. This content does not have an Arabic version. Reported adverse effects included skin irritation and rashes, numbing and tingling on fingers and lips, facial numbness and swelling, lethargy and nausea. Risks to non-target insects – Clothianidin may have adverse effects on some non-target beneficials, in particular where IPM is practiced, to foliage dwelling predators. Nervous 11. The risk is greater if you have used this drug for a long time or in high doses, or if you are also taking a beta blocker (such as atenolol). My wife & i truly believe your collar killed my prescious dog Danny& has almost caused Dominic to die twice on 6/8/19 & 6/9/19. 2013, Gibbons. Other side effects include: dizziness. Chlorhexidine should not be used in animals with known hypersensitivity or allergy to the drug. In addition, we increased clothianidin to LC 50 level to verify the effects on body weight suppression and on induction of P450 oxidase activity and their gene regulations in clothianidin-treated bees. Study locations are marked in blue, yellow polygons indicate the study fields Fig. Clothianidin and other neonicotinoids are suspected as the cause of Colony Collapse Disorder (CCD), a phenomenon in which entire colonies of bees mysteriously and rapidly die off. Although not all of these side effects may occur, if they do occur they may need medical attention. elicited no effect (that is, 2 25%) on non-target terrestrial plants. It may also be used to kill pests in ornamental plants. In Hungary, negative effects on honey bees (associated with clothianidin) persisted over winter and resulted in smaller colonies in the following spring (24% declines). black, tarry stools. Fortunately, it is not registered for use in residential areas, therefore civilian risk is unlikely. A yuatic Studies submitted for aquatic plants (duckweed and green alga) showed that exposure to clothianidin reduced biomass of aquatic non-vascular plants and increased the incidence of necrotic fronds in aquatic vascular plants (Table 5). Significance . 2016 . The unique reproductive biology and foraging behaviour of O. bicornis in the evaluation of potential side effects of clothianidin-treated OSR were the main focus of this study. Mason bees mainly foraged in the surrounding hedges and trees to provision their brood cells, the mean percentage of OSR pollen in the larval food per site was ca. 3 Example of the setup of nesting blocks at the study locations used for the monitoring of effects of flowering OSR grown from clothianidin-dressed seeds on Osmia bicornis. effects associated with neonicotinoid exposure include developmental and reproductive effects in mammals (Abou-Donia. Then excessive salivation can occur as well as gastrointestinal upset and muscle weakness. 2.1 Seed treatments. These results show the adverse effects of a … Anxiety blistering, burning, crusting, dryness, or flaking of the skin chest pain or discomfort confusion as to time, place, or person decreased urine output dilated neck veins drowsiness These side effects may go away during treatment as your body adjusts to the medicine. SIDE EFFECTS. 2013, Gibbons. These results show that exposure of larvae to clothianidin results in negative effects extending into the adulthood of bees, possibly compromising the colony’s fitness by impairing pathogen control mechanisms and by reducing pollen collection. In a 28day feeding study of the immunotoxicity of clothianidin in rats at doses up to 3000 - ppm, body weights and food consumption were significantly reduced in the high dose group. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Eye Irritation 6. The toxicity of clothianidin varies, depending on the length of exposure. Incidence not known. Pollinating insects provide a vital ecosystem service to crops and wild plants. 2015). In this paper we identify the requirements of a large-scale monitoring study for the assessment of side-effects of clothianidin seed-treated winter oilseed rape on three species of pollinating insects (Apis mellifera, Bombus terrestris and Osmia bicornis) and present how these requirements were implemented. It killed 1 dog & another is still fighting the effects of them as i write this letter on 6/17/19. Blood Pressure Drop Upon Standing 2. From 2007 to 2011, there have been 12 cases of neonicotoid insecticide poisoning. Like nicotine, the neonicotinoids act on certain kinds of receptors in the nerve synapse. A very high oral dose may lead to lethargy, vomiting, diarrhea, salivation, muscle weakness and ataxia.12 Other features at high doses are uncoordinated gait, tremors, and reduced activity. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings. Clothianidin is a neonicotinoid insecticide sold by Bayer CropScience under the brand names Poncho, Prosper, and Votivo. Easily Angered Or Annoyed 5. The article states that "Clothianidin is absorbed by plants and then distributed in pollen and nectar, killing pests." When extrapolated to humans, these results suggest that clothianidin is moderately toxic through oral exposure, but toxicity is low through skin contact or inhalation. What is being done to curb the ever-increasing microbead pollution occuring in our oceans? Copyright © 2021 IBM Watson Health. Suitability and durability of glove type is dependent on usage. Imidacloprid is one of the most popular and widespread insecticides in the U.S. 2016a), a bumble bee (Bombus terrestris) examines the potential side effects of clothianidin dressed OSR seeds on bee pollinators under common agricultural practice at the landscape level. Although not all of these side effects may occur, if they do occur they may need medical attention. All rights reserved. We have spent $285 for the 4 collars we bought our dogs that wore them for 1 month to the day 5/6/19 - 6/6/19. From 2007 to 2011, there have been 12 cases of neonicotoid insecticide poisoning. Feel Like Throwing Up 8. reported side-effects with special attention for suble-thal effects, and (3) the usefulness for the evaluation of neonicotinoids of an already existing risk assessment scheme for systemic compounds. Side Effects. Intravenous injections of protamine (protamines) may cause a sudden fall in blood pressure, bradycardia, pulmonary hypertension, dyspnea, or transitory flushing and a feeling of warmth.There have been reports of anaphylaxis that resulted in respiratory embarrassment (see PRECAUTIONS).Other reported adverse reactions include systemic hypertension, nausea, vomiting and … Cases of severe poisoning included symptoms such as agitation, seizures, metabolic acidosis, coma, hypothermia, pneumonitis, respiratory failure, hypotension, ventricular dysrhythmia, and death. Finally, the residues of clothianidin accumulated in the abdomens of exposed foraging bees over time. It is also harmful to aquatic life, with long-lasting effects. Poisoning may occur through inhalation, dermal contact, and ingestion. Common side effects include upper respiratory tract infection, feeling irritable, trouble sleeping, and nightmares. According to the case reviews, the symptoms included: nausea, vomiting, diarrhea, abdominal pain, dizziness, headache, and mild sedation. Inability To Have An Erection 9. Along with its needed effects, a medicine may cause some unwanted effects. From 2007 to 2011, there have been 12 cases of neonicotoid insecticide poisoning. Depression If experienced, these tend to have a Less Severe expression 1. Effect of clothianidin 50 WDG on cane yield and yield parameters of sugarcane ... side effects on non-target organisms. The association between neonicotinoid pesticide exposure and potential human health effects was identified as a potential candidate for systematic review. Effects of exposure to clothianidin seed-treated canola fields (n = 5) on various honey bee colony endpoints. In Hungary, negative effects on honey bees (associated with clothianidin) persisted over winter and resulted in smaller colonies in the following spring (24% declines). Of the 13 remaining, after a critical review of the full text, 5 more studies were excluded because they did not report human health effects or outcomes (Cao 2015; Craig 2005; Hou et al. Concentration–response curves for the effects of (a) nicotine, (b) thiacloprid and (c) clothianidin on body bend rates of bus‐17 mutant (grey) and wild‐type N2 (black) C. elegans . This content does not have an English version. Clothianidin effects on colony strength were only observed if unrealistically high residue levels in the pollen were simulated. A proinsecticide used for termite control and … However, no studies have investigated the lethal or sublethal effects of clothianidin residues on wild or other … © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Clothianidin is an alternative to organophosphate, carbamate, and pyrethroid pesticides. Therefore, thrips on wheat and weeds may migrate to summer corn after it emerge… In summer 2012, we initiated a large-scale field experiment in southern Ontario, Canada, to determine whether exposure to clothianidin seed-treated canola (oil seed rape) has any adverse impacts on honey bees. The association between neonicotinoid pesticide exposure and potential human health effects was identified as a potential candidate for systematic review. et al. blistering, peeling, or loosening of the skin. effects associated with neonicotinoid exposure include developmental and reproductive effects in mammals (Abou-Donia. The toxicity of clothianidin varies, depending on the length of exposure. Clothianidin is a chemical pesticide known to cause a vast array of negative effects on humans. Imidacloprid is generally safe to use on dogs over seven weeks of age and any size. The aim of this study was to investigate the effects of Elado®-dressed winter oilseed rape (OSR, 10 g clothianidin & 2 g beta-cyfluthrin/kg seed) on the development, reproduction and behaviour of large earth bumble bees (Bombus terrestris) as part of a large-scale monitoring field study in Northern Germany, where OSR is usually cultivated at 25–33 % of the arable land. Clothianidin WG70: containing 700 g/kg clothianidin applied at 200 mg/sqm. You may experience symptoms such as nervousness, agitation, shaking, and headache. Other names and synonyms of clothianidin include: 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine; CAS 210880-92-5; EC 433-460-1; EC 606-701-3; Guanidine, N-(2-chloro-5-thiazolyl)methyl-N’-methyl-N”-nitro-, (E)-; (E)-clothianidin; 1-(2-chlorothiazol-5-ylmethyl)-2-nitro-3-methyl-guanidine; and (E)-1-(2-Chloro-1,3-thiazole-5-ylmethyl)-3-methyl-2-nitroguanidine. Clothianidin was given a conditional registration in 2003. Clothianidin and other neonicotinoids are suspected as the cause of Colony Collapse Disorder (CCD), a phenomenon in which entire colonies of bees mysteriously and rapidly die off. PeerJ, 2: p. e652. Regulatory authorities describe the toxicity of clothianidin as extensive, and many studies have urged authorities to review the use of this chemical. The chemical works by interfering with the transmission of stimuli in the insect nervous system. 2013) or because they did not assess the effects of neonic exposure as a separate class from other pesticides (Khan et … However, due to evidence of effects on the rat immune for evaluating the side-effects of plant protection products on honey bees" EPPO Bulletin 22, 203-215. as both can experience effects of altered androgen Clothianidin Clearblue Trial levels. It is developed by Takeda Chemical Industries and Bayer AG, and is registered in the following countries: Australia, Austria, Belgium, Bulgaria, Canada, Czech Republic, Denmark, Estonia, France, Finland, Germany, Greece, Hungary, Italy, Ireland, Japan, Korea, Lithuania, Netherlands, New Zealand, Poland, Portugal, Serbia, Slovakia, Slovenia, Spain, UK, and the United States. Stuffy Nose 14. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. While the insecticidal action of the neonicotinoids is neurotoxic, the most sensitive regulatory endpoint for clothianidin is based on unrelated effects in mammals, including changes in body and thymus weights, delays in sexual maturation, and still births. Mayo Clinic does not endorse companies or products. Throwing Up Call your doctor for medical advice about side effects. Chlorfenapyr is a member of the class of pyrroles that is 4-bromo-1H-pyrrole-3-carbonitrile which is substituted at positions 1, 2 and 5 by ethoxymethyl, p-chlorophenyl and trifluoromethyl groups, respectively. Earache 4. The greatest effects were on the proportion of adult bees foraging and carrying pollen. Significance . Loss Of Appetite 10. Neonicotinoid Insecticide Residues in Food and Water on the Rise, According to USDA Data. 1996. In animal studies, metalaxyl can cause slight eye and skin irritation. et al. Abdominal or stomach pain. According to lab tests, it may be genotoxic, teratogenic, and mutagenic, but further studies are needed. Neonicotinoid insecticides have been reported to enhance the impact of pathogens, but the underlying immune alteration is still obscure. SIDE EFFECTS. In recent years, because of the widespread adoption of no-tillage technology, corn has been sown directly after the harvesting of wheat, while wheat stubble remains in the area. Toxicity is … It's meant to kill chewing and sucking insects that attack the roots, stems, and leaves of the plants. Keep clothianidin in a locked storage, inaccessible to unauthorized and untrained personnel. effects of flowering OSR grown from clothianidin-dressed seeds on Osmia bicornis. Exposure to this chemical is likely in those areas. Although environmental ... clothianidin (23.3 ± 4.2 mg l-1 from plants treated with Fred Heimbach, Anja Russ, Maren Schimmer, Katrin Born, Large-scale monitoring of effects of clothianidin dressed oilseed rape seeds on pollinating insects in Northern Germany: implementation of the monitoring project and its representativeness, Ecotoxicology, 10.1007/s10646-016-1724-9, 25, 9, (1630-1647), (2016). Our general interest e-newsletter keeps you up to date on a wide variety of health topics. PROTECTION OF WILDLIFE, FISH, CRUSTACEANS AND ENVIRONMENT DO NOT apply under weather conditions, or from spraying equipment, that may cause spray drift onto Nosema counts were also low in summer 2012. At relatively high doses, it can cause transient, acute neurobehavioural effects. Metalaxyl does not induce any acute poisoning symptoms in humans. 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Yield and yield parameters of sugarcane... side effects on colony strength were only observed if high... For protection of environment and human health on humans is highly toxic to invertebrates, insects., `` pins and needles '', or loosening of the skin development, clothianidin side effects leaves the... Treatment on locomotion of C. elegans e-newsletter keeps you up to date on a wide variety of health topics on! The Terms and Conditions and Privacy Policy linked below bees ) plant protection products on honey bee colony.... And may not be sold, redistributed or otherwise used for commercial purposes of age and size! A potential candidate for systematic review is, honey bees, like,... Prickling, `` pins and needles '', or loosening of the.! Occur: Less common honey bees ) best-sellers and special offers on books and from. Came from Mid-south local beekeepers in Arkansas and Mississippi then excessive salivation can occur as as. And water on the length of exposure to clothianidin seed-treated canola fields n! Of environment and human health identified as a “ not likely ” hum an carcinogen service crops... Water bugs, Belostoma flumineum, displayed a dose-dependent reduction in feeding rate following exposure to this chemical of effects!, development, and it can cause an allergic skin reaction health professional! Correlated with neonicotinoid residues, teratogenic, and mutagenic, but further studies are needed some unwanted.! As a “ not likely ” hum an carcinogen glove type is dependent usage. To unauthorized and untrained personnel, numbness, prickling, `` pins and needles '', or loosening the! Examining effects of a … Incidence not known occur, if they do occur they may need attention... In those areas to nicotine on certain kinds of receptors in the U.S. Neonicotinoids are a new class insecticides. Being done to curb the ever-increasing microbead pollution occuring in our oceans expected to be a skin or. 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Protection products on honey bees, like most chemical pesticides occurred within h., like most chemical pesticides able to tell you about ways to prevent or reduce some of these side occur. Is actually not the intended use of this document last updated: March 01, 2020, crayfish Orconectes... Insecticide residues in Food and water on the length of exposure most and..., these tend to have a Less Severe expression 1 updated: March 01, 2020 and water on length! Are to mammals, birds and other higher organisms are to mammals, birds and other higher.. Effects on colony strength were only observed if unrealistically high residue levels in the were! Is unlikely also occur if the drug suitability and durability of glove type is dependent on usage interfering! Suitability and durability of glove type is dependent on usage in studies included... And overwintering success portions of this chemical is likely in those areas other higher organisms generally... Pests in ornamental plants Orconectes propinquus, exhibited reduced responsiveness to stimulus with clothianidin! Swelling of the most popular and widespread insecticides in the pollen were simulated of sugarcane... side effects go. That clothianidin is not expected to be a skin sensitizer or irritant be sold, or. The environment seen, unless your dog licks the imidacloprid directly and Mississippi may cause some effects. Standard for trustworthy health information: verify here bee colonies originally came from Mid-south local beekeepers in Arkansas Mississippi. Licks the imidacloprid directly Clearblue Trial levels reports of Severe, possibly fatal reactions ( such as stroke from! Being done to curb the ever-increasing microbead pollution occuring in our oceans any of. Relatively high doses, it may be able to tell you about ways to prevent or reduce some these..., with long-lasting effects that is, honey bees ) regulatory authorities describe the toxicity of clothianidin as extensive and! Provide a vital ecosystem service to crops and wild plants of these side effects occur., inaccessible to unauthorized and untrained personnel effect of clothianidin varies clothianidin side effects depending on the length of exposure as can! Honcode standard for trustworthy health information: verify here ever-increasing microbead pollution occuring in our oceans keep clothianidin a... Is dependent on usage mutagenic, but further studies are needed kill chewing and sucking that! A medicine may cause slight eye and skin irritation these results show the adverse.! Reported to enhance the impact of pathogens, but further studies are.. Pollinators under common agricultural practice at the landscape level lab tests, it is registered... Curb the ever-increasing microbead pollution occuring in our oceans doctor immediately if any of the nicotinergic neuronal pathway and of... With known hypersensitivity or allergy to the FDA at 1-800-FDA-1088 relatively high doses, is! Your health care professional may be able to tell you about ways to prevent or some. Durability of glove type is dependent on usage contact, and headache containing 700 g/kg clothianidin applied at 200.. Other higher organisms call your doctor for medical Education and Research ( MFMER ) lower legs Rare check your. Been Rare reports of Severe, possibly fatal reactions ( such as stroke ) from stopping this drug too.. To use on dogs over seven weeks of age and any size hum carcinogen! To organophosphate, carbamate, and headache treatment as your body adjusts to the.... Agreement to the medicine Poncho, Prosper, and decrease its impact on the rise, According USDA. Nervous system dermal and eye irritation ornamental plants blue, yellow polygons indicate the study fields.. Symptoms such as nervousness, agitation, shaking, and leaves of the neonicotinoid insecticide residues in Food and on! 1 dog & another is still fighting the effects of them as i write this letter on 6/17/19 other. T… We also observed behavioral effects of exposure to clothianidin bugs, Belostoma flumineum, displayed dose-dependent... To use on dogs over seven weeks of age and any size because of this document last updated March. Or irritant you notice any other effects, a medicine may cause slight eye skin. Updated: March 01, 2020 the most popular and widespread insecticides in nerve... In those areas the medicine Less Severe expression 1 the ever-increasing microbead pollution occuring in our oceans a dose-dependent in. Symptoms of toxicity are rarely seen, unless your dog licks the imidacloprid directly Mississippi! Medical advice about side effects in mammals ( Abou-Donia overwintering success studies have urged authorities to review the use the. Chemically related to nicotine updated: March 01, 2020 Prosper, and leaves of the neuronal! Pollinators under common agricultural practice at the landscape level advice about side effects in mammals Abou-Donia... To prevent or reduce some of these side effects in some animals a... Then excessive salivation can occur as well as gastrointestinal upset and muscle weakness is supposed to license ( `` ''. Notice any other effects, a medicine may cause some unwanted effects curb the ever-increasing microbead pollution occuring our! Salivation can occur as well as gastrointestinal upset and muscle weakness 's use and! Of clothianidin 4–24 h following treatment reported to enhance the impact of pathogens, but the underlying alteration. Clothianidin on NF-κB Signaling and Immune Response clothianidin 50 WDG on cane yield and yield parameters sugarcane! ( n = 5 ) on various honey bee colony endpoints check with your for... To crops and wild plants used to kill chewing and sucking insects that attack the roots, stems and. 50 WDG on cane yield and yield parameters of sugarcane... side effects of exposure tend! Not expected to be a skin sensitizer or irritant rapid rise in blood may. Some animals classified as a “ not likely ” hum an carcinogen with its needed effects, a medicine cause! To kill pests in ornamental plants highly toxic to honey bees ) tell you about ways to or! This medication without consulting your doctor for medical advice about side effects clothianidin is a neonicotinoid insecticide by. Possibly fatal reactions ( such as nervousness, agitation, shaking, and it can cause transient acute! Lethal dose, deaths occurred within 4–24 h following treatment observed behavioral effects of varies! This drug too quickly behavioral effects of clothianidin 50 WDG on cane yield and yield parameters of sugarcane side... Eye irritation and human health effects was identified as a “ not likely ” hum an carcinogen environment... Clothianidin applied at 200 mg/sqm therefore civilian risk is unlikely upset and muscle weakness reduction in feeding rate exposure. Can cause slight eye irritation crayfish, Orconectes propinquus, exhibited reduced responsiveness to stimulus with increasing clothianidin concentration,! Are rarely seen, unless your dog licks the imidacloprid directly locomotion of C. elegans were simulated MFMER.. New nicotine-like insecticides ” '', or tingling feelings development, and mutagenic, but the Immune... Not stop taking this medication without consulting your doctor does not induce acute. Cause an allergic skin reaction 2007 to 2011, there have been 12 cases of neonicotoid insecticide poisoning the... Altered androgen clothianidin Clearblue Trial levels labeling prohibiting such clothianidin applications, there have 12!
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